2024
Joey H. Li, Adalia Zhou, Cassidy D. Lee, Siya N. Shah, Jeong Hyun Ji, Vignesh Senthilkumar, Eddie T. Padilla, Andréa Ball, Qinyan Feng, Christian G. Bustillos, Luke Riggan, Alain Greige, Ajit S. Divakaruni, Fran Annese, Jessica Cooley-Coleman, Steven A. Skinner, Christopher W. Cowan, Timothy E. O’Sullivan. MEF2C regulates NK cell effector functions through control of lipid metabolism. Nature Immunology (2024).
Leen Hermans, and Timothy E. O’Sullivan. No time to die: Epigenetic regulation of natural killer cell survival. Immunological Reviews (2024).
Rui Li, Cristian Camilo Galindo, Dominique Davidson, Huaijian Guo, Ming-Chao Zhong, Jin Qian, Bin Li, Zsolt Ruzsics, Colleen M. Lau, Timothy E. O’Sullivan, Silvia M. Vidal, Joseph C. Sun, and Andre ́ Veillette . Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48. Cell Reports (2024).
2023
Andrew D. Hildreth, Eddie T. Padilla, Meha Gupta, Yung Yu Wong, Ryan Sun, Akshara R. Legala, and Timothy E. O’Sullivan. Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production. Nature Metabolism (2023).
Joey H. Li, Matthew R. Hepworth, & Timothy E. O’Sullivan. Regulation of systemic metabolism by tissue-resident immune cell circuits. Immunity (2023).
Mandy I. Cheng, Joey H. Li, Luke Riggan,, Bryan Chen, Rana Yakhshi Tafti, Scott Chin, Feiyang Ma, Matteo Pellegrini, Haley Hrncir, Arthur P. Arnold, Timothy E. O’Sullivan, and Maureen A. Su. The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences. Nature Immunology (2023).
Andrew D. Hildreth, Eddie T. Padilla, Rana Yakhshi Tafti, Akshara R. Legala, and Timothy E. O’Sullivan. Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production, Cell Reports (2023).
Iona S. Schister, Xavier Y.X. Sng, Colleen M. Lau, David R. Powell, Orr-El Weizman, Peter Fleming, Georgia E.G. Neate, Valentina Voigt, Sam Sheppard, Andreas I. Marakovsky, Sheridan Daly, Motoko Koyama, Geoffrey R. Hill, Stephen Turner, Timothy E O’Sullivan, Joseph C Sun, Christopher Andoniou, Maripia A. Degli-Esposti. Infection induces tissue-resident memory NK cells that safeguard tissue health. Immunity (2023).
Benjamin Krämer, Ansel P. Nalin, Feiyang Ma, Sarah Eickhoff, Philipp Lutz, Sonia Leonardelli, Felix Goeser, Claudia Finnemann, Gudrun Hack, Jan Raabe, Michael ToVinh, Sarah Ahmad, Christoph Hoffmeister, Kim M. Kaiser, Steffen Manekeller, Vittorio Branchi, Tobias Bald, Michael Hölzel, Robert Hüneburg, Hans Dieter Nischalke, Alexander Semaan, Bettina Langhans, Dominik J. Kaczmarek, Brooke Benner, Matthew R. Lordo, Jesse Kowalski, Adam Gerhardt, Jörg Timm, Marieta Toma, Raphael Mohr, Andreas Türler, Arthur Charpentier, Tobias van Bremen, Georg Feldmann, Arne Sattler, Katja Kotsch, Ali T. Abdallah, Christian P. Strassburg, Ulrich Spengler, William E. Carson III, Bethany L. Mundy-Bosse, Matteo Pellegrini, Timothy E. O’Sullivan, Aharon G. Freud, Jacob Nattermann. Single-cell RNA sequencing identifies a population of human liver-type ILC1s. Cell Reports (2023).
2022
Jianming Wang, Chun-yuan Chang, Xue Yang, Fan Zhou, Juan Liu, Sining Zhu, Xuezhong Yu, Cen Liu, Timothy E. O’Sullivan, Ping Xie, Zhaohui Feng, Wenwei Hu. Leukemia inhibitory factor protects against graft-versus-host disease while preserving graft-versus-leukemia activity. Blood (2022).
Luke Riggan, Feiyang Ma, Joey H. Li, Elizabeth Fernandez, David A. Nathanson, Matteo Pellegrini, and Timothy E. O’Sullivan. Fli1 restricts the formation of memory precursor NK cells during viral infection. Nature Immunology (2022).
Li, J.H., and O’Sullivan, T.E. Back to the Future:Spatiotemporal determinants of antitumor NK cell function. Frontiers in Immunology. (2022).
2021
Hildreth, A.D., Ma F., Wong Y.Y., Sun R., Pellegrini M., and O’Sullivan T.E. Single cell sequencing of human white adipose tissue identifies novel cell states in health and in obesity. Nature Immunology (2021).
Riggan, L., Shah, S., and O’Sullivan, T.E. Arrested Development: NK cell Suppression in the Tumor Microenvironment. Clinical and Translational Immunology. (2021).
2020
Hildreth, A.D., Riggan, L., and O’Sullivan T.E. CRISPR Cas9 ribonucleoprotein-mediated genomic editing in primary innate immune cells. STAR Protocols (2020).
Riggan, L., Hildreth, A.D., Rolot, M., Wong Y.Y., Satyadi, W., Sun, R., Huerta, C., and O’Sullivan, T.E. CRISPR Cas9 ribonucleoprotein-mediated genomic editing in primary mature innate immune cells. Cell Reports (2020)
Nabekura, S., Riggan, L. Hildreth, A.D., O’Sullivan, T.E., and Shibuya A. Type 1 Innate Lymphoid Cells Protect Mice from Acute Liver Injury via Interferon-γ Secretion for Upregulating Bcl-xL Expression in Hepatocytes. Immunity. (2020)
2019
O’Sullivan, T.E. Dazed and Confused: NK cells. Frontiers in Immunology. (2019)
Riggan, L., Freud, A.G., & O’Sullivan, T.E. True Detective: Unraveling Group 1 Innate Lymphocyte Heterogeneity. Trends in Immunology. (2019)
Orr-El Weizman, Eric Song, Nicholas M. Adams, Andrew D. Hildreth, Luke Riggan, Chirag Krishna, Oscar A. Aguilar, Christina S. Leslie, James R. Carlyle, Joseph C. Sun , and Timothy E. O’Sullivan. Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12. Nature Immunology (2019)
Hildreth A.D., and O’Sullivan T.E. Tissue-resident Innate and Innate-like Lymphocyte Responses to Viral Infection. Viruses. 11(3) 272 (2019)
2017
Rapp Moritz, Lau Colleen M, Adams Nicholas M, Weizman Orr-El, O'Sullivan Timothy E, Geary Clair D, Sun Joseph C Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses. Science Immunology. 2017
Weizman Orr-El, Adams Nicholas M, Schuster Iona, Krishna Chirag, Pritykin Yuri, Lau Colleen, Degli-Esposti Mariapia A, Leslie Christina S, Sun Joseph C, O'Sullivan Timothy E ILC1 Confer Early Host Protection at Initial Sites of Viral Infection. Cell. 2017; 171: 795-808.
O'Sullivan Timothy E, Sun Joseph C Innate Lymphoid Cell Immunometabolism. Journal of molecular biology. 2017; 429(23): 3577-3586 .
2016
O'Sullivan Timothy E, Rapp Moritz, Fan Xiying, Weizman Orr-El, Bhardwaj Priya, Adams Nicholas M, Walzer Thierry, Dannenberg Andrew J, Sun Joseph C Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance. Immunity. 2016; 45(2): 428-41.
Saddawi-Konefka Robert, Seelige Ruth, Gross Emilie T E, Levy Eric, Searles Stephen C, Washington Allen, Santosa Endi K, Liu Beichen, O'Sullivan Timothy E, Harismendy Olivier, Bui Jack D Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance. Cell reports. 2016; 16(9): 2348-58.
O'Sullivan Timothy E, Geary Clair D, Weizman Orr-El, Geiger Theresa L, Rapp Moritz, Dorn Gerald W, Overholtzer Michael, Sun Joseph C Atg5 Is Essential for the Development and Survival of Innate Lymphocytes. Cell reports. 2016; 15(9): 1910-9.
2015
O'Sullivan Timothy E, Sun Joseph C, Lanier Lewis L Natural Killer Cell Memory. Immunity. 2015; 43(4): 634-45.
O'Sullivan Timothy E, Johnson Lexus R, Kang Helen H, Sun Joseph C BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory. Immunity. 2015; 43(2): 331-42.
O'Sullivan Timothy E, Sun Joseph C Generation of Natural Killer Cell Memory during Viral Infection. Journal of innate immunity. 2015; 7(6): 557-62.
2014
Geiger Theresa L, Abt Michael C, Gasteiger Georg, Firth Matthew A, O'Connor Margaret H, Geary Clair D, O'Sullivan Timothy E, van den Brink Marcel R, Pamer Eric G, Hanash Alan M, Sun Joseph C Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens. The Journal of experimental medicine. 2014; 211(9): 1723-31.
O'Sullivan Timothy, Saddawi-Konefka Robert, Gross Emilie, Tran Miller, Mayfield Stephen P, Ikeda Hiroaki, Bui Jack D Interleukin-17D mediates tumor rejection through recruitment of natural killer cells. Cell reports. 2014; 7(4): 989-98.
2012
O'Sullivan Timothy, Saddawi-Konefka Robert, Vermi William, Koebel Catherine M, Arthur Cora, White J Michael, Uppaluri Ravi, Andrews Daniel M, Ngiow Shin Foong, Teng Michele W L, Smyth Mark J, Schreiber Robert D, Bui Jack D Cancer immunoediting by the innate immune system in the absence of adaptive immunity. The Journal of experimental medicine. 2012; 209(10): 1869-82.
2011
O'Sullivan Timothy, Dunn Gavin P, Lacoursiere Daphne Y, Schreiber Robert D, Bui Jack D Cancer immunoediting of the NK group 2D ligand H60a. Journal of immunology (Baltimore, Md. : 1950). 2011; 187(7): 3538-45.